Deterministic genomic screening for bacteriophage therapeutics
Automated genomic audit evaluating genome completeness, strictly virulent lytic compliance, and absence of antimicrobial resistance or virulence factors — producing evidence dossiers that disclose exactly which methods ran.
What a screen reports
Is the genome complete enough to judge?
Estimates how much of the phage genome is present by comparing it against complete viral genomes, checks the assembly is a single contiguous sequence, and checks its length falls in the range therapeutic phages occupy. A genome that fails here is not screened further, because a partial sequence cannot be cleared on genes it may simply be missing.
Would this phage make its host more dangerous?
Searches for antibiotic resistance genes and for bacterial toxin and virulence genes the phage could carry into a host. Separately, it looks for the integrase, recombinase and excisionase genes a phage uses to insert itself into host DNA, over two independent gene predictions, and predicts lifestyle from the protein domains the genome carries. One disqualifying finding fails the genome.
Does it carry what a therapy needs?
Names the genome's genes and reports the machinery that makes a phage usable: the lysis cassette it uses to kill its host, the receptor-binding proteins that set which bacteria it can attack, and the capsid and packaging proteins that build the particle. Genes a sequence search cannot name are named again by their predicted 3D structure.
What is this phage related to?
Places the genome among classified reference phages by the genes they share. It runs only when you ask for it, takes longer than the rest of the screen, and never changes a run's result.
Ready to evaluate candidate phage genomes?
Upload raw FASTA sequences to receive a full biosafety and quality audit and a downloadable evidence dossier.
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